Our services

We provide high-quality, cost-effective in vivo and ex vivo models and state-of-the-art technologies, including in vivo imaging, single-cell and bulk RNA sequencing, spatial transcriptomics, proteomics, super-resolution microscopy and AI-assisted histology analysis to study acute and chronic kidney disease and diabetic nephropathy. 
Below are some of the models and methods that we currently offer. Contact us to learn more about our services and what we can offer you.

Models

Acute kidney injury (AKI)
  • Bilateral/unilateral ischemia reperfusion injury (IRI)
  • Anti-GBM glomerulonephritis
  • Cecal ligation and puncture (CLP)
  • Lipopolysaccharide (LPS)-induced systemic inflammation
  • Cisplatin-induced AKI
  • Folic acid-induced AKI

Chronic kidney disease (CKD)
  • Adenine-induced nephropathy
  • 5/6 nephrectomy
  • Adriamycin-induced nephropathy

Diabetic nephropathy (DN)
  • Streptozotocin (STZ)-induced DN
  • ReninAAV, Unx, db/db model of accelerated DN

Methods

Plasma and urine biomarkers
  • BUN, creatinine and cystatin C
  • Albumin-creatinine ratio (uACR), NGAL and Kim-1
  • Luminex® assays and Olink® proteomics

Tissue analysis
  • Histology (HE, PAS and Sirius red) with AI-assisted assessment
  • Immunohistochemistry, multiplex immunofluorescence and RNAscope® in situ hybridization (ISH)
  • Electron microscopy and Magnephy® super-resolved 3D imaging
  • Bulk- and single nuclei RNA sequencing, 10x® spatial transcriptomics

In vivo analysis
  • MediBeacon® transdermal GFR system
  • Resazurin tubular function assay
  • CODA® noninvasive blood pressure system
  • In vivo imaging (IVIS®, μCT, PET/MRI, MPI and ultrasound)